02904nas a2200289   4500008004100000020004100041245011100082210006900193250001500262260000800277300001400285490000700299520193300306653002702239653003802266653004102304653001902345653001102364653001402375653003102389100001502420700001302435700001202448700001602460700001302476856012502489       2009                        eng d  a0315-162X (Print)0315-162X (Linking)00aProgress in assessing physical function in arthritis: PROMIS short forms and computerized adaptive testing0 aProgress in assessing physical function in arthritis PROMIS shor  a2009/09/10  cSep  a2061-20660 v363 aOBJECTIVE: Assessing self-reported physical function/disability with the Health Assessment Questionnaire Disability Index (HAQ) and other instruments has become central in arthritis research. Item response theory (IRT) and computerized adaptive testing (CAT) techniques can increase reliability and statistical power. IRT-based instruments can improve measurement precision substantially over a wider range of disease severity. These modern methods were applied and the magnitude of improvement was estimated. METHODS: A 199-item physical function/disability item bank was developed by distilling 1865 items to 124, including Legacy Health Assessment Questionnaire (HAQ) and Physical Function-10 items, and improving precision through qualitative and quantitative evaluation in over 21,000 subjects, which included about 1500 patients with rheumatoid arthritis and osteoarthritis. Four new instruments, (A) Patient-Reported Outcomes Measurement Information (PROMIS) HAQ, which evolved from the original (Legacy) HAQ; (B) "best" PROMIS 10; (C) 20-item static (short) forms; and (D) simulated PROMIS CAT, which sequentially selected the most informative item, were compared with the HAQ. RESULTS: Online and mailed administration modes yielded similar item and domain scores. The HAQ and PROMIS HAQ 20-item scales yielded greater information content versus other scales in patients with more severe disease. The "best" PROMIS 20-item scale outperformed the other 20-item static forms over a broad range of 4 standard deviations. The 10-item simulated PROMIS CAT outperformed all other forms. CONCLUSION: Improved items and instruments yielded better information. The PROMIS HAQ is currently available and considered validated. The new PROMIS short forms, after validation, are likely to represent further improvement. CAT-based physical function/disability assessment offers superior performance over static forms of equal length.10a*Disability Evaluation10a*Outcome Assessment (Health Care)10aArthritis/diagnosis/*physiopathology10aHealth Surveys10aHumans10aPrognosis10aReproducibility of Results1 aFries, J F1 aCella, D1 aRose, M1 aKrishnan, E1 aBruce, B  uhttp://www.iacat.org/content/progress-assessing-physical-function-arthritis-promis-short-forms-and-computerized-adaptive01227nas a2200229   4500008004100000245014700041210006900188300001100257490000700268520046800275100001300743700001300756700001600769700001600785700001300801700001300814700001200827700001500839700001300854700001200867856011800879       2007                        eng d00aThe Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years0 aPatientReported Outcomes Measurement Information System PROMIS p  aS3-S110 v453 aThe National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) Roadmap initiative (www.nihpromis.org) is a 5-year cooperative group program of research designed to develop, validate, and standardize item banks to measure patient-reported outcomes (PROs) relevant across common medical conditions. In this article, we will summarize the organization and scientific activity of the PROMIS network during its first 2 years.1 aCella, D1 aYount, S1 aRothrock, N1 aGershon, RC1 aCook, KF1 aReeve, B1 aAder, D1 aFries, J F1 aBruce, B1 aRose, M  uhttp://www.iacat.org/content/patient-reported-outcomes-measurement-information-system-promis-progress-nih-roadmap01914nas a2200157   4500008004100000245010500041210006900146300001000215490000700225520132900232653003401561100001501595700001301610700001301623856012001636       2005                        eng d00aThe promise of PROMIS: using item response theory to improve assessment of patient-reported outcomes0 apromise of PROMIS using item response theory to improve assessme  aS53-70 v233 aPROMIS (Patient-Reported-Outcomes Measurement Information System) is an NIH Roadmap network project intended to improve the reliability, validity, and precision of PROs and to provide definitive new instruments that will exceed the capabilities of classic instruments and enable improved outcome measurement for clinical research across all NIH institutes. Item response theory (IRT) measurement models now permit us to transition conventional health status assessment into an era of item banking and computerized adaptive testing (CAT). Item banking uses IRT measurement models and methods to develop item banks from large pools of items from many available questionnaires. IRT allows the reduction and improvement of items and assembles domains of items which are unidimensional and not excessively redundant. CAT provides a model-driven algorithm and software to iteratively select the most informative remaining item in a domain until a desired degree of precision is obtained. Through these approaches the number of patients required for a clinical trial may be reduced while holding statistical power constant. PROMIS tools, expected to improve precision and enable assessment at the individual patient level which should broaden the appeal of PROs, will begin to be available to the general medical community in 2008.10acomputerized adaptive testing1 aFries, J F1 aBruce, B1 aCella, D  uhttp://www.iacat.org/content/promise-promis-using-item-response-theory-improve-assessment-patient-reported-outcomes